An old Sioux shaman asks Jack Slade to come to the Twin Peaks Sioux Reservation to look into a series of killings that have apparently been perpetrated by a rogue wolf. When he arrives at the reservation, Slade discovers that the killings are being done by a Sioux who shape shifts into the form of a wolf. Slade's discovery that similar killings happening in a nearby town are being done by a second shape shifter leads him to the additional discovery of a plot by the killer to instigate a rebellion by the Sioux residents of the town. When the grand daughter of the old shaman is kidnapped, Slade races against time to save her life and prevent the Sioux uprising.

A Chief Financial Officer and his lovely assistant discover their employer, in conjunction with the U. S. government, is running a clandestine operation manufacturing bio-chemical weapons. The company and the government discover they know about the operation, which puts their lives in danger. They ask Jack Slade for help. Blood flows and corpses stack up as Slade goes against two different security teams and federal agents as he battles for justice. In an exciting finale, Slade must confront an army of cyborgs.